Toxin Name δ-theraphotoxin-Hm1b
Source Species Heteroscodra  maculata (Togo starburst tarantula)
Toxin Group Theraphotoxin
Description δ-theraphotoxin-Hm1b is a gating modifier toxin that inhibits inactivation of voltage-gated sodium channels. When tested against human Nav1.1–1.8 α subunits heterologously expressed in Xenopus oocytes, the toxin specifically inhibited inactivation of Nav1.1 (EC50 = 100 nM), with little effect on Nav1.2–1.8. The toxin is a homolog of δ-theraphotoxin-Hm1a, which was isolated from the venom of the same species.

Intraplantar injection of the toxin in mice causes equivalent mechanical sensitisation to its paralog δ-theraphotoxin-Hm1a.
Discovered 2016
Sex: female, Prosoma length: 20mm
Photo courtesy of Bastian Rast
Use of photo governed by creative
commons noncommercial license
This toxin last updated on Nov 02, 2016

Taxonomy
Biological Activity
Accessions
Literature References
Protein Information
Sequences
Toxin Synonyms