Toxin Name δ-theraphotoxin-Hm1b
Source Species Heteroscodra  maculata (Togo starburst tarantula)
Toxin Group Theraphotoxin
Description δ-theraphotoxin-Hm1b is a gating modifier toxin that inhibits inactivation of voltage-gated sodium channels. When tested against human Nav1.1–1.8 α subunits heterologously expressed in Xenopus oocytes, the toxin specifically inhibited inactivation of Nav1.1 (EC50 = 100 nM), with little effect on Nav1.2–1.8. The toxin is a homolog of δ-theraphotoxin-Hm1a, which was isolated from the venom of the same species.

Intraplantar injection of the toxin in mice causes equivalent mechanical sensitisation to its paralog δ-theraphotoxin-Hm1a.
Discovered 2016
Sex: female, Prosoma length: 20mm
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This toxin last updated on Nov 02, 2016

Biological Activity
Literature References
Protein Information
Toxin Synonyms