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| Toxin Name |
CRISP-1-Lycosa singoriensis |
| Source Species |
Lycosa singoriensis |
| Toxin Group |
Lycotoxin |
| Description |
Venom allergen, similar to that found in hymenopterans. Belongs to the CAP protein family that includes CRISP proteins, antigen 5, and pathogenesis-related (PR-1) proteins. Has been convergently recruited into the venom of a variety of animals, including cepahalopods, cone snails, scorpions, reptiles and ticks, as well as the saliva of hematophagous insects. CAP domain proteins are the dominant allergy-inducing toxins in hymenopteran venoms. Its function in spider venoms remains to be determined. |
| Discovered |
2004 |
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Sex: female, Prosoma length: 8mm
Photo courtesy of Bastian Rast
Use of photo governed by creative
commons noncommercial license
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| This toxin last updated on Oct 29, 2014 |
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| Current Taxonomy |
Historic Taxonomy |
| Kingdom |
Animalia |
| Phylum |
Arthropoda |
| Class |
Arachnida |
| Order |
Araneae |
| Infra-order |
Araneomorphae |
| Family |
Lycosidae |
| Genus |
Lycosa |
| Species |
singoriensis |
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| "Allohogna" "singoriensis" |
| "Aranea" "singoriensis" |
| "Aranea" "tarentula" |
| "Arctosa" "latreillii" |
| "Arctosa" "singoriensis" |
| "Lycosa" "latreillii" |
| "Lycosa" "rossica" |
| "Lycosa" "singoriensis" |
| "Lycosa" "tarentuloides singoriensis" |
| "Lycosa" "ucrainensis" |
| "Trochosa" "singoriensis" |
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| Molecular Target |
ED50 |
IC50 |
Kd |
Pharmacophore |
Comment |
| Molecular target unknown |
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| Original Deposition References |
Zhang,Y. and Liang,S.
Unpublished
Transcriptome analysis of the venom gland of the Chinese wolf spider Lycosa Singoriensis
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| Other References |
Fry B.G., Roelants K., Champagne D.E., Scheib H., Tyndall J.D., King G.F., Nevalainen T.J., Norman J.A., Lewis R.J., Norton R.S., Renjifo C., de la Vega R.C.
Annu Rev Genomics Hum Genet 10:483-511 (2009).
The toxicogenomic multiverse: convergent recruitment of proteins into animal venoms.
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| Peptide Sequences |
>as:CRISP-1-Lycosa singoriensis|sp:A9QQ26 CRISP-1-Lycosa singoriensis (Venom allergen (antigen 5)) from the spider Lycosa singoriensis (translated cDNA sequence)
MSAPVGIPSLLLALCALLCVLNAVRSAYCPDPYKRYSDQHSYCVGVCCSCAKYRRGVSPW
LKKELVRLHNNLRSKVAGGKSHSVDHLPRATNMLEMVWDDELAEVAQRWSDKCERKSDCE
DCRRVGRFGVGQIIFEFDGKMDGKDMENEFFSRFMALQSFRKEQVARFTAGTNPKTAQIL
WAKTWRIGCGFLDFNYPGNGRRYTQIVCNYGPKGNEEGEEVYKAGSVCSSCPANTCCGDA
CKKHNLKANYHGLCKVIDENLPPEGNVPHKKTGNEVFYCGFNDESDCRHTVEGVDRWIRN
VTTGGTWLNTYLGNYGHTVIEVRSAHHLQVRQAMPGHQDPQWTHGGRTTLSVPAVRGFGG
GRQILNLTHLPPCRR |
Full BLAST
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| mRNA Sequences |
>as:CRISP-1-Lycosa singoriensis|gb:ABX75373 CDNA sequence encoding CRISP-1-Lycosa singoriensis (venom allergen (antigen 5)) from the spider Lycosa singoriensis
GACATTACAGAAAATATGTCTGCTCCGGTGGGAATCCCAAGCCTGCTCCTGGCTCTGTGC
GCGCTGCTGTGCGTGCTGAACGCAGTCAGGTCCGCGTACTGCCCGGACCCCTACAAGCGG
TACAGCGACCAGCACTCGTACTGCGTGGGCGTTTGCTGTTCCTGCGCCAAATACAGAAGG
GGCGTCAGCCCGTGGCTCAAGAAGGAGCTGGTGAGGCTTCACAACAACCTCAGGAGCAAA
GTGGCCGGAGGAAAGTCCCACTCGGTCGACCACTTGCCCAGAGCCACTAACATGCTGGAG
ATGGTATGGGACGACGAGCTGGCAGAGGTAGCTCAGAGGTGGAGCGACAAGTGCGAGAGG
AAGAGCGACTGCGAGGACTGCAGGAGAGTCGGCCGCTTTGGTGTGGGCCAGATCATCTTT
GAATTCGACGGGAAGATGGACGGAAAGGACATGGAGAACGAATTCTTCAGCCGCTTCATG
GCTCTGCAGAGTTTCAGGAAGGAGCAAGTGGCGCGCTTCACGGCCGGCACCAATCCCAAG
ACGGCCCAGATCCTGTGGGCCAAGACGTGGCGCATCGGCTGCGGTTTCTTGGACTTCAAC
TACCCCGGCAACGGCAGACGCTACACCCAAATTGTCTGCAACTACGGGCCTAAAGGCAAC
GAGGAAGGCGAGGAGGTGTACAAGGCCGGCAGTGTATGCTCGTCGTGTCCGGCCAACACC
TGTTGTGGCGACGCCTGCAAGAAGCACAACCTGAAAGCTAACTACCACGGACTCTGCAAG
GTCATCGATGAGAACCTGCCCCCAGAGGGCAATGTGCCCCACAAGAAGACCGGCAACGAG
GTGTTCTACTGCGGTTTCAACGATGAATCTGACTGCAGACACACCGTGGAAGGAGTGGAT
CGATGGATCAGAAACGTGACCACCGGAGGTACTTGGTTGAACACCTATTTGGGCAACTAC
GGCCACACGGTTATTGAAGTTCGATCAGCCCATCACCTCCAAGTCCGGCAAGCTATGCCT
GGCCATCAGGACCCGCAGTGGACCCATGGAGGCCGGACAACCCTATCGGTACCAGCTGTC
AGGGGTTTTGGAGGAGGAAGGCAAATTCTCAACCTCACTCATCTTCCCCCCTGCAGACGA
TAATGTGAAGCATAGGTTCCATACAGACTACTTCCAGCCGTCCGAGTTTCCGAAAAACAG
GGGATCTAAGCTGACCCTCAGCTTCTCAGTGGGTGCTGAAGGTCCGAAGCAGTACTTGGA
AATCGATAGTATAGTGGCGTTGGAAAAGGACTGCCCGAAGAAGACCATCACAGAAGGAAC
CGGGTTCATCACCTCACGATGAAGAATCCCTTCCACTTCCAGATGCTCAATTTTCAATAA
AGTTAACGATTAAGTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA |
Full BLAST
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| Synonym |
Type |
| CRISP-1-Lycosa singoriensis |
Recommended full name |
| Venom allergen |
Synonym |
| Antigen 5 |
Synonym |
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