 |
|
 |
| |
| Toxin Name |
U7-ctenitoxin-Pn1b (N-terminal fragment) |
| Source Species |
Phoneutria nigriventer (Brazilian armed spider) |
| Toxin Group |
Ctenitoxin |
| Description |
Toxin with undetermined molecular target. The toxin is lethal to mice. |
| Discovered |
1990 |
|
Sex: female, Prosoma length: 13mm
Photo courtesy of Bastian Rast
Use of photo governed by creative
commons noncommercial license
|
| This toxin last updated on Jul 27, 2010 |
|
| Current Taxonomy |
Historic Taxonomy |
| Kingdom |
Animalia |
| Phylum |
Arthropoda |
| Class |
Arachnida |
| Order |
Araneae |
| Infra-order |
Araneomorphae |
| Family |
Ctenidae |
| Genus |
Phoneutria |
| Species |
nigriventer |
|
| Ctenus paca |
| Ctenus rufichelis |
| Phoneutria fera |
| Phoneutria luederwaldti |
| Phoneutria nigriventer |
| Phoneutria paca |
| Phoneutria rufichelis |
| Ctenus luederwaldti |
| Ctenus nigriventer |
|
|
| Molecular Target |
ED50 |
IC50 |
Kd |
Pharmacophore |
Comment |
| Molecular target unknown |
|
|
|
|
|
| Taxon |
ED50 |
LD50 |
PD50 |
Qualitative Information |
| Mus musculus |
6.4
pmol/g
|
|
|
Native toxin causes flaccid paralysis after intra cerebro-ventricular injection in mice. ED50 calculated based on literature value of 40 µg/kg and M=6250 Da.
|
| Mus musculus |
|
21.9
pmol/g
|
|
LD50 calculated based on literature value of 137 µg/kg and M=6250 Da.
|
|
| Source |
Accession |
| ArachnoServer
|
AS000275 |
| NCBI_Taxon
|
6918
|
| PIR
|
C39305
|
| UniProt
|
P31010
|
|
| Original Deposition References |
Rezende L. Jr., Cordeiro M.N., Oliveira E.B., Diniz C.R.
Toxicon 29:1225-1233(1991).
Isolation of neurotoxic peptides from the venom of the 'armed' spider Phoneutria nigriventer.
|
|
| Peptide Sequences |
>as:U7-ctenitoxin-Pn1b|sp:P31010 Toxin from venom of the spider Phoneutria nigriventer with unknown molecular target
GCIGRNESQKKDNVYKFKE |
Full BLAST |
BLAST mature toxin only
|
|
| Synonym |
Type |
| U7-ctenitoxin-Pn1b |
Recommended full name |
| U7-CNTX-Pn1b |
Recommended abbreviation |
| Neurotoxin Tx3 |
Synonym |
| U26-ctenitoxin-Pn1a |
Synonym |
| Tx3 |
Synonym (abbreviation) |
| U26-CNTX-Pn1a |
Synonym (abbreviation) |
|
|
|
|
|
 |
|
 |
|
|
