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| Toxin Name |
δ-theraphotoxin-Cg2a |
| Source Species |
Chilobrachys guangxiensis |
| Toxin Group |
Theraphotoxin |
| Description |
Toxin from the theraphosid spider Chilobrachys guangxiensis which inhibits the inactivation of voltage-gated sodium channels. The toxins slows down channel inactivation by shifting voltage dependence of activation to more depolarised potentials. A binding site different to sites 3 and 4 on sodium channels is suggested for the toxin |
| Discovered |
2008 |
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Sex: female, Prosoma length: 29mm
Photo courtesy of Bastian Rast
Use of photo governed by creative
commons noncommercial license
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| This toxin last updated on Mar 22, 2016 |
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| Current Taxonomy |
| Kingdom |
Animalia |
| Phylum |
Arthropoda |
| Class |
Arachnida |
| Order |
Araneae |
| Infra-order |
Mygalomorphae |
| Family |
Theraphosidae |
| Genus |
Chilobrachys |
| Species |
guangxiensis |
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| Molecular Target |
ED50 |
IC50 |
Kd |
Pharmacophore |
Comment |
| Sodium channel, voltage-gated (vertebrate): Vertebrate NaV channel, non-selective |
1.77
μM
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0.9
μM
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Toxin inhibits TTX-S sodium channels in DRG (EC50 = 1.77 μM) and TTX-R sodium channels in rat cardiac myocytes (IC50 = 0.9 μM). |
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| Original Deposition References |
Chen J., Deng M., He Q., Meng E., Jiang L., Liao Z., Rong M., Liang S.
Cell. Mol. Life Sci. 65:2431-2444(2008).
Molecular diversity and evolution of cystine knot toxins of the tarantula Chilobrachys jingzhao.
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| Other References |
Wang M., Diao J., Li J., Tang J., Lin Y., Hu W., Zhang Y., Xiao Y., Liang S.
Toxicon 52:871-880(2008).
JZTX-IV, a unique acidic sodium channel toxin isolated from the spider Chilobrachys jingzhao.
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Liao Z., Cao J., Li S., Yan X., Hu W., He Q., Chen J., Tang J., Xie J., Liang S.
Proteomics 7:1892-1907(2007).
Proteomic and peptidomic analysis of the venom from Chinese tarantula Chilobrachys jingzhao.
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| Disulfide Bonds |
Posttranslational modifications |
| Left Residue |
Right Residue |
Evidence |
| 2 |
16 |
By homology |
| 9 |
21 |
By homology |
| 15 |
28 |
By homology |
|
| Residue Number |
Type |
Symbol |
| 34 |
C-terminal amidation (By similarity) |
NH₂ |
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| Peptide Sequences |
>as:δ-theraphotoxin-Cg2a_1|sp:B1P1F3 Toxin from venom of the spider Chilobrachys guangxiensis which inhibits voltage-gated sodium channels
MKVSVVITLAVLGVMFVWASAAELEERGSDQRDSPAWIKSMERIFQSEERECTKFLGGCS
EDSECCPHLGCKDVLYYCAWDGTFGK |
Full BLAST |
BLAST mature toxin only
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>as:δ-theraphotoxin-Cg2a_2|sp:B1P1F4 Toxin from venom of the spider Chilobrachys guangxiensis which inhibits voltage-gated sodium channels
MKVSVVITLAVLGIMFVWASAAELEERGSDQRDSPAWLKSMERIFQSEERECTKFLGGCS
EDSECCPHLGCKDVLYYCAWDGTFGK |
Full BLAST |
BLAST mature toxin only
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>as:δ-theraphotoxin-Cg2a_3|sp:P0CH56 Toxin from venom of the spider Chilobrachys guangxiensis which inhibits voltage-gated sodium channels
MKVSVVITLAVLGVMFVWASAAELKERGSDQRDSPAWIKSMERIFQSEERECTKFLGGCS
EDSECCPHLGCKDVLYYCAWDGTFGK |
Full BLAST |
BLAST mature toxin only
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| mRNA Sequences |
>as:δ-theraphotoxin-Cg2a_1 cDNA sequence of a toxin from the venom gland of the spider Chilobrachys guangxiensis
GAGTTTAGTCTGAACTAAAGGTTCAGTTTTCACATACTGCGGATTCACCTGTTTGATTAG
TTGCTGGTAACCGTACTGCACTGAAGACAATGAAGGTTTCAGTAGTAATAACTTTGGCTG
TATTGGGGGTGATGTTTGTTTGGGCTTCTGCTGCTGAACTAGAAGAACGTGGTTCGGATC
AGAGGGACTCGCCTGCATGGATAAAATCTATGGAGAGAATATTTCAGTCTGAAGAAAGAG
AATGCACGAAATTCCTTGGAGGCTGTAGCGAAGATTCGGAATGCTGTCCACACTTGGGAT
GCAAAGATGTGCTCTATTATTGTGCATGGGATGGGACCTTCGGCAAATGAGAAATCCTGA
TTACAATGAAGATTTTTTGAATTGCCTCTTTGGATTCACGATGTTCGGTTTAAAAGTTGT
CAATAAATGAATACCACAAGAAAAAAAAAAAAAAAAAAAAAA |
Full BLAST
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>as:δ-theraphotoxin-Cg2a_2 cDNA sequence of a toxin from the venom gland of the spider Chilobrachys guangxiensis
TTTTCACATACTGCGGATTCACCTGTTTGATTAGTTGCTGGTAACCGTACTGCACTGAAG
ACAATGAAGGTTTCAGTAGTAATAACTTTGGCTGTATTGGGGATAATGTTTGTTTGGGCT
TCCGCTGCTGAACTGGAAGAACGTGGTTCGGATCAGAGGGACTCGCCTGCATGGCTAAAA
TCTATGGAGAGAATATTTCAGTCTGAAGAAAGAGAATGCACGAAATTCCTTGGAGGCTGT
AGCGAAGATTCGGAATGCTGTCCACACTTGGGATGCAAAGATGTGCTCTATTATTGTGCA
TGGGATGGGACCTTCGGCAAATGAGAAATTCTGATTACAATGAAGATTTTTTGAATTGCC
TCTTTGGATTCACGATGTTCGGTTTAAAAGTTGTCAATAAATGAATACCACAAGAAAAAA
AAAAAAAAAAAAA |
Full BLAST
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>as:δ-theraphotoxin-Cg2a_3 cDNA sequence of a toxin from the venom gland of the spider Chilobrachys guangxiensis
AATTTAATCTGAACTAAAGGTTCAGTTTTCACATACTGCGGATTCACCTGTTTGATTAGT
TGCTGGTAACCGTACTGCACTGAAGACAATGAAGGTTTCAGTAGTAATAACTTTGGCTGT
ATTGGGGGTGATGTTTGTTTGGGCTTCTGCTGCTGAACTAAAAGAACGTGGTTCGGATCA
GAGGGACTCGCCTGCATGGATAAAATCTATGGAGAGAATATTTCAGTCTGAAGAAAGAGA
ATGCACGAAATTCCTTGGAGGCTGTAGCGAAGATTCGGAATGCTGTCCACACTTGGGATG
CAAAGATGTGCTCTATTATTGTGCATGGGATGGGACCTTCGGCAAATGAGAAATCCTGAT
TACAATGAAGATTTTTTGAATTGCCTCTTTGGATTCACGATGTTCGGTTTAAAAGTTGTC
AATAAATGAATACCACAAGAAAAAAAAAAAAAAAAAAAAAA |
Full BLAST
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| Synonym |
Type |
| δ-theraphotoxin-Cg2a |
Recommended full name |
| δ-TRTX-Cg2a |
Recommended abbreviation |
| U17-theraphotoxin-Cj1a |
Synonym |
| Jingzhaotoxin-4 |
Synonym |
| μ-theraphotoxin-Cg2a |
Synonym |
| Jingzhaotoxin-31.2 |
Synonym |
| Jingzhaotoxin-4 |
Synonym |
| Jingzhaotoxin-31 |
Synonym |
| μ-theraphotoxin-Cg2a |
Synonym |
| JZTX-31 |
Synonym (abbreviation) |
| JZTX-4 |
Synonym (abbreviation) |
| JZTX-IV |
Synonym (abbreviation) |
| JZTX-31.2 |
Synonym (abbreviation) |
| U17-TRTX-Cj1a |
Synonym (abbreviation) |
| μ-TRTX-Cj2a |
Synonym (abbreviation) |
| μ-TRTX-Cg2a |
Synonym (abbreviation) |
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