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| Toxin Name |
TCTP1-1-Loxosceles intermedia |
| Source Species |
Loxosceles intermedia |
| Toxin Group |
Sicaritoxin |
| Description |
Translationally-controlled tumor protein homolog 1 from the spider Loxosceles intermedia . This venom protein causes edema, enhances vascular permeability and is likely related to the inflammatory activity of the venom. |
| Discovered |
2014 |
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Sex: Female, Prosoma length: 4mm
Photo courtesy of Bastian Rast
Use of photo governed by creative
commons noncommercial license
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| This toxin last updated on Aug 11, 2015 |
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| Current Taxonomy |
Historic Taxonomy |
| Kingdom |
Animalia |
| Phylum |
Arthropoda |
| Class |
Arachnida |
| Order |
Araneae |
| Infra-order |
Araneomorphae |
| Family |
Sicariidae |
| Genus |
Loxosceles |
| Species |
intermedia |
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| Loxosceles intermedia |
| Loxosceles ornata |
| Loxosceles ornatus |
| Loxosceles spadicea |
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| Molecular Target |
ED50 |
IC50 |
Kd |
Pharmacophore |
Comment |
| Molecular target unknown |
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| Original Deposition References |
Sade Y.B., Boia-Ferreira M., Gremski L.H., da Silveira R.B., Gremski W., Senff-Ribeiro A., Chaim O.M., Veiga S.S.
Int. J. Biochem. Cell Biol. 44:170-177(2012).
Molecular cloning, heterologous expression and functional characterization of a novel translationally-controlled tumor protein (TCTP) family member from Loxosceles intermedia (brown spider) venom.
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| Peptide Sequences |
>as:TCTP1-1-Loxosceles intermedia|sp:G3LU44 Translationally-controlled tumor protein homolog from the venom of the spider Loxosceles intermedia
MIIFKDLLTGDEMFTDSSKYKVVDGCLYEVECRHISRRHGDIQLDGANPSQEEADEATDD
IVESGLDLVLNQRLIETGFSKNDYKVYLKGYTKALQDKWKEMEKSESEINEAKTKLTEAV
KKVLPKLSDLQFFMGESSNPDGLIALLEYRQVDEKEVPIMMFFKHGLDEEKV |
Full BLAST
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| mRNA Sequences |
>as:TCTP1-1-Loxosceles intermedia|ENA:JN544929 Translationally-controlled tumor protein homolog from the venom of the spider Loxosceles intermedia
GTTGCCGTGGCCGTTGCGTACTTTATTTCGAGGTGTGTTTACATTCGCTTCCATCGACAA
AAATGATCATTTTTAAGGATTTATTAACAGGAGACGAGATGTTCACTGACTCCTCGAAGT
ATAAAGTGGTCGACGGCTGCTTGTATGAAGTGGAATGTCGTCATATTTCACGAAGACATG
GAGATATTCAGCTCGATGGAGCCAATCCGTCACAAGAAGAAGCTGATGAGGCTACTGATG
ACATTGTAGAATCTGGACTTGACTTGGTTCTAAATCAGCGTTTAATTGAAACTGGTTTTT
CAAAAAATGACTATAAAGTGTATTTAAAAGGATATACTAAAGCCTTACAAGATAAATGGA
AAGAAATGGAAAAATCAGAAAGTGAAATTAATGAAGCAAAGACAAAATTAACAGAAGCTG
TGAAAAAAGTCTTACCAAAGCTTAGTGACTTGCAGTTTTTCATGGGAGAAAGTTCGAATC
CAGATGGTTTGATTGCATTGCTAGAATACCGTCAAGTAGATGAAAAGGAAGTTCCAATAA
TGATGTTCTTTAAACATGGTTTGGACGAAGAAAAAGTTTAACCCATTTTGAGTTGTACTA
TTGGAAAGCTGCTTGTCAGAATCGGTCATCAAAATGATTGGCAAGTGTACATACCATTGA
TAACAAGCGTGCCTTTGTTTATTTATCAAGATAATAGATTATATTTCATGAATCTTTTAC
TTGTGGCTTTATGTACTACAACTTTGATTTATGAACAATATGCAAATATGTAAAGTCAAT
AAAGATGCTTCAGATTTTTGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAA |
Full BLAST
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| Synonym |
Type |
| TCTP1-1-Loxosceles intermedia |
Recommended full name |
| Translationally-controlled tumor protein homolog |
Synonym |
| LiTCTP |
Synonym |
| Histamine-releasing factor |
Synonym |
| HRF |
Synonym |
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