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| Toxin Name |
U2-agatoxin-Ao1a |
| Source Species |
Agelena orientalis |
| Toxin Group |
Agatoxin |
| Description |
The toxin was identified from venom gland mRNA and it has a sequence identical to the insecticidal U2-agatoxin-Aop1a from the venom of the related species Allagelena opulenta, which causes rapid but reversible paralysis in crickets and has no activity in mammals. |
| Discovered |
2004 |
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Sex: Female, Prosoma length: 5mm
Photo courtesy of Bastian Rast
Use of photo governed by creative
commons noncommercial license
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| This toxin last updated on Aug 20, 2010 |
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| Current Taxonomy |
Historic Taxonomy |
| Kingdom |
Animalia |
| Phylum |
Arthropoda |
| Class |
Arachnida |
| Order |
Araneae |
| Infra-order |
Araneomorphae |
| Family |
Agelenidae |
| Genus |
Agelena |
| Species |
orientalis |
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| Agelena taurica |
| Agelena gracilens taurica |
| Agelena labyrinthica orientalis |
| Agelena orientalis |
| Agelena similis taurica |
| Agelena syriaca |
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| Molecular Target |
ED50 |
IC50 |
Kd |
Pharmacophore |
Comment |
| Molecular target unknown |
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| Taxon |
ED50 |
LD50 |
PD50 |
Qualitative Information |
| Gryllus bimaculatus |
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291.0
pmol/g
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Synthetic toxin, by injection.
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| Original Deposition References |
Kozlov S., Malyavka A., Grishin E., McCutchen B., Lu A., Schepers E., Herrmann R.
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
Predicted toxin-like structures from spider venom glands mRNA.
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| Other References |
Kozlov S., Malyavka A., McCutchen B., Lu A., Schepers E., Herrmann R., Grishin E.
Proteins Apr 1;59(1):131-40(2005).
A novel strategy for the identification of toxinlike structures in spider venom.
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| Disulfide Bonds |
Posttranslational modifications |
| Left Residue |
Right Residue |
Evidence |
| 3 |
19 |
Experimentally determined |
| 10 |
24 |
Experimentally determined |
| 18 |
34 |
Experimentally determined |
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| Residue Number |
Type |
Symbol |
| 35 |
C-terminal amidation (By similarity) |
NHâ‚‚ |
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| Peptide Sequences |
>as:U2-agatoxin-Ao1a|sp:Q5Y4Y5 Translation of mRNA sequence for toxin U2-agatoxin-Ao1a from spider Agelena orientalis.
MRAIISLFLISAMVFSMIQAVPEEEGLQLSEDERGGCLPHNRFCNALSGPRCCSGLKCKE
LSIWDSRCLG |
Full BLAST |
BLAST mature toxin only
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| mRNA Sequences |
>as:U2-agatoxin-Ao1a|gb:AY681297 mRNA sequence of toxin U2-agatoxin-Ao1a from spider Agelena orientalis.
GCACGAGGAATAGAAGTTTACTACAATTCTTGTGCTGGACAAAAGGATTATAATAAAATA
ACAATGAGAGCTATCATTTCTCTGTTCCTTATTTCTGCAATGGTCTTCTCCATGATTCAA
GCTGTACCCGAAGAAGAAGGTTTACAGCTTTCTGAAGATGAAAGGGGAGGATGTCTTCCT
CATAATAGATTTTGTAATGCATTGAGTGGTCCAAGGTGCTGCTCAGGATTAAAATGCAAG
GAATTAAGCATTTGGGATAGCAGATGTCTTGGATAGAAGACGGATGGAAAAAATCTCTGA
TTTCAACTTGTTACCAACATTTGAATTGAAATATCAAACTGGAGTATATATCAAAATTCT
ATATATGTTAATTCATATTATGAAATTCTGTATTTCTGATCATTTAAATAAAATATAATG
CAATTTT |
Full BLAST
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| Synonym |
Type |
| U2-agatoxin-Ao1a |
Recommended full name |
| U2-AGTX-Ao1a |
Recommended abbreviation |
| Agelenin |
Synonym |
| Agel 00 |
Synonym (abbreviation) |
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